Deregulation of the Wnt pathway is a hallmark of col-orectal cancer (CRC). Nevertheless, the clinical implications of aberrant β-catenin-driven gene transcription remain elusive. We herein present a transcriptional WNT signaturepredicting survival outcomes in metastatic CRC (mCRC).
Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer / Goeman, Frauke; De Nicola, Francesca; Amoreo, Carla Azzurra; Scalera, Stefano; Marinelli, Daniele; Sperati, Francesca; Mazzotta, Marco; Terrenato, Irene; Pallocca, Matteo; Ciuffreda, Ludovica; Sperandio, Eleonora; Barba, Maddalena; Pizzuti, Laura; Sergi, Domenico; Amodio, Antonella; Paoletti, Giancarlo; Krasniqi, Eriseld; Vici, Patrizia; Casini, Beatrice; Gallo, Enzo; Buglioni, Simonetta; Diodoro, Maria Grazia; Pescarmona, Edoardo; Vitale, Ilio; De Maria, Ruggero; Grazi, Gian Luca; Ciliberto, Gennaro; Fanciulli, Maurizio; Maugeri-Saccà, Marcello. - In: CLINICAL AND TRANSLATIONAL MEDICINE. - ISSN 2001-1326. - STAMPA. - 10:(2020), pp. e199-1-e199-5. [10.1002/ctm2.199]
Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer
Grazi, Gian Luca;
2020
Abstract
Deregulation of the Wnt pathway is a hallmark of col-orectal cancer (CRC). Nevertheless, the clinical implications of aberrant β-catenin-driven gene transcription remain elusive. We herein present a transcriptional WNT signaturepredicting survival outcomes in metastatic CRC (mCRC).
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