Deregulation of the Wnt pathway is a hallmark of col-orectal cancer (CRC). Nevertheless, the clinical implications of aberrant β-catenin-driven gene transcription remain elusive. We herein present a transcriptional WNT signaturepredicting survival outcomes in metastatic CRC (mCRC).
Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer / Goeman, F., De Nicola, F., Amoreo, C.A., Scalera, S., Marinelli, D., Sperati, F., Mazzotta, M., Terrenato, I., Pallocca, M., Ciuffreda, L., Sperandio, E., Barba, M., Pizzuti, L., Sergi, D., Amodio, A., Paoletti, G., Krasniqi, E., Vici, P., Casini, B., Gallo, E., et al.. - In: CLINICAL AND TRANSLATIONAL MEDICINE. - ISSN 2001-1326. - STAMPA. - 10:(2020), pp. e199-1-e199-5. [10.1002/ctm2.199]
Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer
Grazi, Gian Luca;
2020
Abstract
Deregulation of the Wnt pathway is a hallmark of col-orectal cancer (CRC). Nevertheless, the clinical implications of aberrant β-catenin-driven gene transcription remain elusive. We herein present a transcriptional WNT signaturepredicting survival outcomes in metastatic CRC (mCRC).
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