P392Preliminary evaluation of stress myocardial blood flow pattern in patients with apical hypertrophic cardiomyopathy candidate to be enrolled in the CARAPACE study

The apical variant of HCM is associated with regional stress hypoperfusion of the apex in the majority of patients. Similar to septal HCM, global stress MBF values are heterogeneous and distributed within the whole disease-specific spectrum of flow-values, with no correlation between global MBF values and visual detection of perfusion defects. There was no correlation between global stress MBF values and abnormal apical TPG. Collectively, these data are in agreement with those observed in the classical septal HCM, despite the peculiar anatomy and genetic basis. These data support the inclusion of apical HCM in the CARAPACE trial.