Analysis of the Timing of Puberty in a Recent Cohort of Italian Girls: Evidence for Earlier Onset Compared to Previous Studies

Background: Throughout the 20 century, in developed countries there has been a secular trend toward earlier menarche. Over the past 2 decades, however, there has been an apparent stabilization in the average age of menarche age in most Western countries. Objectives: The objective of this study was to analyze the mean age of menarche in a cohort of Italian girls, to analyze the mean age of breast button appearance (B2), and to correlate the B2 developmental stage and age at menarche with the most important clinical and auxological parameters. Materials and Methods: We retrospectively evaluated the data of 1458 Italian girls born between 1995 and 2003. We collected the main auxological and clinical parameters, including age at B2, age at menarche, height, weight, and body mass index (BMI) at B2 and menarche and, when possible, adult/near adult height. Results: The mean age of B2 was 10.16 +/- 1.00 years, significantly earlier than previously reported for Italian girls ( P < .05); the mean age of menarche was 12.07 +/- 0.99 years, also significantly earlier than previously reported ( P < .0 0 01). Age at B2 and menarche inversely correlated with BMI standard deviation score (SDS) ( P < .0 0 01). The mean adult/near adult height of the girls in the study cohort was not statistically different from previously reported data for Italian women. Conclusions: Our results suggest a new trend for an earlier appearance of thelarche and menarche in Italian girls. Our data confirm a significant relationship between BMI and age of B2 and menarche. The girls' final height seems to be in line with average height for the