Congenital hypothyroidism (CH) is a relatively frequent congenital endocrine disorder, caused by defective production of thyroid hormones (THs) at birth. Because THs are essential for the development of normal neuronal networks, CH is also a common preventable cause of irreversible intellectual disability (ID) in children. Prolonged hypothyroidism, particularly during the THs-dependent processes of brain development in the first years of life, due to delays in diagnosis, inadequate timing and dosing of levothyroxine (l-thyroxine or l-T-4), the non-compliance of families, incorrect follow-up and the interference of foods, drugs and medications affecting the absorption of l-T-4, may be responsible for more severe ID. In this review we evaluate the main factors influencing levels of THs and the absorption of l-T-4 in order to provide a practical guide, based on the existing literature, to allow optimal follow-up for these patients.

An Overview on Different L-Thyroxine (l-T4) Formulations and Factors Potentially Influencing the Treatment of Congenital Hypothyroidism During the First 3 Years of Life / Stagi, Stefano; Municchi, Giovanna; Ferrari, Marta; Wasniewska, Malgorzata Gabriela. - In: FRONTIERS IN ENDOCRINOLOGY. - ISSN 1664-2392. - ELETTRONICO. - 13:(2022), pp. 0-0. [10.3389/fendo.2022.859487]

An Overview on Different L-Thyroxine (l-T4) Formulations and Factors Potentially Influencing the Treatment of Congenital Hypothyroidism During the First 3 Years of Life

Stagi, Stefano;Ferrari, Marta;
2022

Abstract

Congenital hypothyroidism (CH) is a relatively frequent congenital endocrine disorder, caused by defective production of thyroid hormones (THs) at birth. Because THs are essential for the development of normal neuronal networks, CH is also a common preventable cause of irreversible intellectual disability (ID) in children. Prolonged hypothyroidism, particularly during the THs-dependent processes of brain development in the first years of life, due to delays in diagnosis, inadequate timing and dosing of levothyroxine (l-thyroxine or l-T-4), the non-compliance of families, incorrect follow-up and the interference of foods, drugs and medications affecting the absorption of l-T-4, may be responsible for more severe ID. In this review we evaluate the main factors influencing levels of THs and the absorption of l-T-4 in order to provide a practical guide, based on the existing literature, to allow optimal follow-up for these patients.
2022
13
0
0
Stagi, Stefano; Municchi, Giovanna; Ferrari, Marta; Wasniewska, Malgorzata Gabriela
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1302735
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