Electroclinical Features and Long-term Seizure Outcome in Patients With Eyelid Myoclonia With Absences

Emanuele Cerulli Irelli,; View ORCID ProfileEnrico Cocchi,; View ORCID ProfileGeorgia Ramantani,; Caraballo, Roberto H.; Giuliano, Loretta; View ORCID ProfileTulay Yilmaz,; Morano, Alessandra; Panagiotakaki, Eleni; Operto, Francesca F.; Beatriz Gonzalez Giraldez,; Silvennoinen, Katri; Casciato, Sara; Comajuan, Marion; Balestrini, Simona; View ORCID ProfileFrancesco Fortunato,; Coppola, Antonietta; Giancarlo Di Gennaro,; View ORCID ProfileAngelo Labate,; Sofia, Vito; Kluger, Gerhard J.; Kasteleijn-Nolst Trenité, Dorothée G. A.; View ORCID ProfileAntonio Gambardella,; Baykan, Betul; Sisodiya, Sanjay M.; View ORCID ProfileAlexis Arzimanoglou,; View ORCID ProfilePasquale Striano,; Carlo Di Bonaventura,; on behalf of the EMA Study Group,

Eyelid myoclonia (EM) with absences (EMA) is a generalized epilepsy syndrome with a prognosis and clinical characteristics that are still partially undefined. We investigated electroclinical endophenotypes and long-term seizure outcome in a large cohort of patients with EMA. In this multicenter retrospective study, patients with EMA with ≥5 years of follow-up were included. We investigated prognostic patterns and sustained terminal remission (STR), along with their prognostic factors. Moreover, a 2-step cluster analysis was used to investigate the presence of distinct EMA endophenotypes.

Electroclinical Features and Long-term Seizure Outcome in Patients With Eyelid Myoclonia With Absences / Emanuele Cerulli Irelli, View ORCID ProfileEnrico Cocchi, View ORCID ProfileGeorgia Ramantani, Roberto H. Caraballo, Loretta Giuliano, View ORCID ProfileTulay Yilmaz, Alessandra Morano, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Simona Balestrini, View ORCID ProfileFrancesco Fortunato, Antonietta Coppola, Giancarlo Di Gennaro, View ORCID ProfileAngelo Labate, Vito Sofia, Gerhard J. Kluger, Dorothée G.A. Kasteleijn-Nolst Trenité, View ORCID ProfileAntonio Gambardella, Betul Baykan, Sanjay M. Sisodiya, View ORCID ProfileAlexis Arzimanoglou, View ORCID ProfilePasquale Striano, Carlo Di Bonaventura, on behalf of the EMA Study Group. - In: NEUROLOGY. - ISSN 0028-3878. - ELETTRONICO. - (2022), pp. 1865-1876.