MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that play a role in regulating gene expression in a tissue-specific manner. Placental miRNAs expression pattern dynamically changes during pregnancy influencing cell proliferation, differentiation and apoptosis. Changes of specific miRNA levels have been described in pregnancies complicated by hypertensive disorders or gestational diabetes and a growing interest in understanding miRNA role on placental development and placental disorders is currently going on. The present review evaluates the possible roles of miRNAs in trophoblastic invasion and placental development as well as their potential role as biomarkers for the prediction of placental disorders focusing the attention on intrauterine growth restriction.

Trophoblast microRNAs (miRNAs), preeclampsia and intrauterine growth restriction / Spataro, Elisa; Pasquini, Lucia; Luceri, Cristina; Petraglia, Felice. - In: MINERVA OBSTETRICS AND GYNECOLOGY. - ISSN 2724-6450. - ELETTRONICO. - (2022), pp. 1-5. [10.23736/S2724-606X.22.05109-0]

Trophoblast microRNAs (miRNAs), preeclampsia and intrauterine growth restriction

Spataro, Elisa
;
Pasquini, Lucia;Luceri, Cristina;Petraglia, Felice
2022

Abstract

MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that play a role in regulating gene expression in a tissue-specific manner. Placental miRNAs expression pattern dynamically changes during pregnancy influencing cell proliferation, differentiation and apoptosis. Changes of specific miRNA levels have been described in pregnancies complicated by hypertensive disorders or gestational diabetes and a growing interest in understanding miRNA role on placental development and placental disorders is currently going on. The present review evaluates the possible roles of miRNAs in trophoblastic invasion and placental development as well as their potential role as biomarkers for the prediction of placental disorders focusing the attention on intrauterine growth restriction.
2022
1
5
Spataro, Elisa; Pasquini, Lucia; Luceri, Cristina; Petraglia, Felice
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1303987
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