We investigated 3 cohorts of COVID-MPN patients, observed since the beginning of the SARS-CoV2, from February 2020 to June 2022. In the European MPN-COVID registry, promoted by the LeukemiaNet (ELN) (clinicaltrials.gov: NCT04385160), 863 MPN patients with COVID-19 have been enrolled, and in 649 of them, information on the vaccination status was provided. diagnosis of covid-19 required a positive real-time reverse transcriptase polymerase chain reaction from nasal swab and symptoms highly suggestive for sars-cov-2 infection. according to the most prevalent circulating vocs in europe at that time, 4 waves were identified: 1st, February to June 2020 (wild-type original variant) 2nd, July 2020–June 2021 (alpha/beta/ gamma); 3rd, July 2021–December 2021 (delta); and wave 4th, January to June 2022 (Omicron). The severity of COVID-19 was categorized as asymptomatic, mild, moderate or severe/critical according to the NIH COVID-19 Treatment Guidelines
Breakthrough infections in MPN-COVID vaccinated patients / Barbui, Tiziano; Carobbio, Alessandra; Ghirardi, Arianna; Iurlo, Alessandra; De Stefano, Valerio; Sobas, Marta Anna; Rumi, Elisa; Elli, Elena Maria; Lunghi, Francesca; Gasior Kabat, Mercedes; Cuevas, Beatriz; Guglielmelli, Paola; Bonifacio, Massimiliano; Marchetti, Monia; Alvarez-Larran, Alberto; Fox, Laura; Bellini, Marta; Daffini, Rosa; Benevolo, Giulia; Carreno-Tarragona, Gonzalo; Patriarca, Andrea; Al-Ali, Haifa Kathrin; Andrade-Campos, Maria Marcio Miguel; Palandri, Francesca; Harrison, Claire; Foncillas, Maria Angeles; Osorio, Santiago; Koschmieder, Steffen; Magro Mazo, Elena; Kiladjian, Jean-Jacques; Bolaños Calderón, Estefanía; Heidel, Florian H; Quiroz Cervantes, Keina; Griesshammer, Martin; Garcia-Gutierrez, Valentin; Sanchez, Alberto Marin; Hernandez-Boluda, Juan Carlos; Lopez Abadia, Emma; Carli, Giuseppe; Sagues Serrano, Miguel; Kusec, Rajko; Xicoy Cirici, Blanca; Guenova, Margarita; Navas Elorza, Begona; Angona, Anna; Cichocka, Edyta; Kulikowska de Nałęcz, Anna; Cattaneo, Daniele; Bucelli, Cristina; Betti, Silvia; Borsani, Oscar; Cavalca, Fabrizio; Carbonell, Sara; Curto-Garcia, Natalia; Benajiba, Lina; Rambaldi, Alessandro; Vannucchi, Alessandro Maria. - In: BLOOD CANCER JOURNAL. - ISSN 2044-5385. - ELETTRONICO. - 12:(2022), pp. 154-154. [10.1038/s41408-022-00749-8]
Breakthrough infections in MPN-COVID vaccinated patients
Guglielmelli, Paola;Palandri, Francesca;Betti, Silvia;Vannucchi, Alessandro Maria
2022
Abstract
We investigated 3 cohorts of COVID-MPN patients, observed since the beginning of the SARS-CoV2, from February 2020 to June 2022. In the European MPN-COVID registry, promoted by the LeukemiaNet (ELN) (clinicaltrials.gov: NCT04385160), 863 MPN patients with COVID-19 have been enrolled, and in 649 of them, information on the vaccination status was provided. diagnosis of covid-19 required a positive real-time reverse transcriptase polymerase chain reaction from nasal swab and symptoms highly suggestive for sars-cov-2 infection. according to the most prevalent circulating vocs in europe at that time, 4 waves were identified: 1st, February to June 2020 (wild-type original variant) 2nd, July 2020–June 2021 (alpha/beta/ gamma); 3rd, July 2021–December 2021 (delta); and wave 4th, January to June 2022 (Omicron). The severity of COVID-19 was categorized as asymptomatic, mild, moderate or severe/critical according to the NIH COVID-19 Treatment Guidelines
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