We investigated 3 cohorts of COVID-MPN patients, observed since the beginning of the SARS-CoV2, from February 2020 to June 2022. In the European MPN-COVID registry, promoted by the LeukemiaNet (ELN) (clinicaltrials.gov: NCT04385160), 863 MPN patients with COVID-19 have been enrolled, and in 649 of them, information on the vaccination status was provided. diagnosis of covid-19 required a positive real-time reverse transcriptase polymerase chain reaction from nasal swab and symptoms highly suggestive for sars-cov-2 infection. according to the most prevalent circulating vocs in europe at that time, 4 waves were identified: 1st, February to June 2020 (wild-type original variant) 2nd, July 2020–June 2021 (alpha/beta/ gamma); 3rd, July 2021–December 2021 (delta); and wave 4th, January to June 2022 (Omicron). The severity of COVID-19 was categorized as asymptomatic, mild, moderate or severe/critical according to the NIH COVID-19 Treatment Guidelines
Breakthrough infections in MPN-COVID vaccinated patients / Barbui, T., Carobbio, A., Ghirardi, A., Iurlo, A., De Stefano, V., Sobas, M.A., Rumi, E., Elli, E.M., Lunghi, F., Gasior Kabat, M., Cuevas, B., Guglielmelli, P., Bonifacio, M., Marchetti, M., Alvarez-Larran, A., Fox, L., Bellini, M., Daffini, R., Benevolo, G., Carreno-Tarragona, G., et al.. - In: BLOOD CANCER JOURNAL. - ISSN 2044-5385. - ELETTRONICO. - 12:(2022), pp. 154-154. [10.1038/s41408-022-00749-8]
Breakthrough infections in MPN-COVID vaccinated patients
Guglielmelli, Paola;Palandri, Francesca;Betti, Silvia;Vannucchi, Alessandro Maria
2022
Abstract
We investigated 3 cohorts of COVID-MPN patients, observed since the beginning of the SARS-CoV2, from February 2020 to June 2022. In the European MPN-COVID registry, promoted by the LeukemiaNet (ELN) (clinicaltrials.gov: NCT04385160), 863 MPN patients with COVID-19 have been enrolled, and in 649 of them, information on the vaccination status was provided. diagnosis of covid-19 required a positive real-time reverse transcriptase polymerase chain reaction from nasal swab and symptoms highly suggestive for sars-cov-2 infection. according to the most prevalent circulating vocs in europe at that time, 4 waves were identified: 1st, February to June 2020 (wild-type original variant) 2nd, July 2020–June 2021 (alpha/beta/ gamma); 3rd, July 2021–December 2021 (delta); and wave 4th, January to June 2022 (Omicron). The severity of COVID-19 was categorized as asymptomatic, mild, moderate or severe/critical according to the NIH COVID-19 Treatment Guidelines
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