Approximately one-third of all subacute cutaneous lupus erythematous (SCLE) cases are drug-induced. Herein is reported a case of SCLE in a 73-year-old man occurred after the second dose of COVID-19 mRNA BNT162b2 vaccine (Comirnaty/Pfizer). A score of 6 (probable association) at the Naranjo Normogram suggested a causal association between COVID 19 vaccine booster and its onset. Possible mechanisms through which COVID-19 vaccine can trigger autoimmunity are also discussed.
Subacute cutaneous lupus erythematosus induced by Pfizer COVID-19 vaccine / Elisabetta Magnaterra, Manfredi Magliulo, Elena Biancamaria Mariotti, Valentina Ruffo Di Calabria, Lavinia Quintarelli, Alberto Corrà, Cristina Aimo, Alice Verdelli, Marzia Caproni. - In: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY. - ISSN 2784-8450. - ELETTRONICO. - (2023), pp. 0-0. [10.23736/S2784-8671.23.07373-5]
Subacute cutaneous lupus erythematosus induced by Pfizer COVID-19 vaccine
Elisabetta Magnaterra
;Manfredi Magliulo;Elena Biancamaria Mariotti;Valentina Ruffo Di Calabria;Lavinia Quintarelli;Cristina Aimo;Alice Verdelli;Marzia Caproni
2023
Abstract
Approximately one-third of all subacute cutaneous lupus erythematous (SCLE) cases are drug-induced. Herein is reported a case of SCLE in a 73-year-old man occurred after the second dose of COVID-19 mRNA BNT162b2 vaccine (Comirnaty/Pfizer). A score of 6 (probable association) at the Naranjo Normogram suggested a causal association between COVID 19 vaccine booster and its onset. Possible mechanisms through which COVID-19 vaccine can trigger autoimmunity are also discussed.
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