Background: Recently, several case-control studies demonstrated an association between gliptins and bullous pemphigoid (BP) occurrence. However, data on the clinical and immunologic features of gliptinassociated bullous pemphigoid (GABP) are controversial.Objective: This study aimed to clinically and immunologically characterize a large cohort of GABP patients to get an insight into the pathophysiology of this emerging drug-induced variant of BP.Methods: Seventy-four GABP patients were prospectively enrolled and characterized from 9 different Italian dermatology units between 2013 and 2020.Results: Our findings demonstrated the following in the GABP patients: (1) a noninflammatory phenotype, which is characterized by low amounts of circulating and skin-infiltrating eosinophils, is frequently found; (2) immunoglobulin (Ig)G, IgE, and IgA humoral responses to BP180 and BP230 antigens are reduced in frequency and titers compared with those in patients with idiopathic BP; (3) IgG reactivity targets multiple BP180 epitopes other than noncollagenous region 16A.Limitations: A limitation of the study is that the control group did not comprise only type 2 diabetes mellitus patients with BP.Conclusion: GABP patients show peculiar features of anti-BP180 and-BP230 humoral responses, laying the foundation for diagnostic improvements and getting novel insights into understanding the mechanism of BP onset. ( J Am Acad Dermatol 2022;87:56-63.)

Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study / Salemme A.; Fania L.; Scarabello A.; Caproni M.; Marzano A.V.; Cozzani E.; Feliciani C.; De Simone C.; Papini M.; Satta R.R.; Parodi A.; Mariotti F.; Lechiancole S.; Genovese G.; Passarelli F.; Festa F.; Bellei B.; Provini A.; Sordi D.; Pallotta S.; Abeni D.; Mazzanti C.; Didona B.; Di Zenzo G.. - In: JAAD INTERNATIONAL. - ISSN 2666-3287. - ELETTRONICO. - 87:(2022), pp. 56-63. [10.1016/j.jaad.2022.02.036]

Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study

Caproni M.;
2022

Abstract

Background: Recently, several case-control studies demonstrated an association between gliptins and bullous pemphigoid (BP) occurrence. However, data on the clinical and immunologic features of gliptinassociated bullous pemphigoid (GABP) are controversial.Objective: This study aimed to clinically and immunologically characterize a large cohort of GABP patients to get an insight into the pathophysiology of this emerging drug-induced variant of BP.Methods: Seventy-four GABP patients were prospectively enrolled and characterized from 9 different Italian dermatology units between 2013 and 2020.Results: Our findings demonstrated the following in the GABP patients: (1) a noninflammatory phenotype, which is characterized by low amounts of circulating and skin-infiltrating eosinophils, is frequently found; (2) immunoglobulin (Ig)G, IgE, and IgA humoral responses to BP180 and BP230 antigens are reduced in frequency and titers compared with those in patients with idiopathic BP; (3) IgG reactivity targets multiple BP180 epitopes other than noncollagenous region 16A.Limitations: A limitation of the study is that the control group did not comprise only type 2 diabetes mellitus patients with BP.Conclusion: GABP patients show peculiar features of anti-BP180 and-BP230 humoral responses, laying the foundation for diagnostic improvements and getting novel insights into understanding the mechanism of BP onset. ( J Am Acad Dermatol 2022;87:56-63.)
2022
87
56
63
Salemme A.; Fania L.; Scarabello A.; Caproni M.; Marzano A.V.; Cozzani E.; Feliciani C.; De Simone C.; Papini M.; Satta R.R.; Parodi A.; Mariotti F.; Lechiancole S.; Genovese G.; Passarelli F.; Festa F.; Bellei B.; Provini A.; Sordi D.; Pallotta S.; Abeni D.; Mazzanti C.; Didona B.; Di Zenzo G.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1309081
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