Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties / Biagiotti, Giacomo; Toniolo, Gianluca; Albino, Martin; Severi, Mirko; Andreozzi, Patrizia; Marelli, Marcello; Kokot, Hana; Tria, Giancarlo; Guerri, Annalisa; Sangregorio, Claudio; Rojo, Javier; Berti, Debora; Marradi, Marco; Cicchi, Stefano; Urbančič, Iztok; van Kooyk, Yvette; Chiodo, Fabrizio; Richichi, Barbara. - In: NANOSCALE HORIZONS. - ISSN 2055-6756. - ELETTRONICO. - 8:(2023), pp. --.776---.782. [10.1039/d3nh00063j]

Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Biagiotti, Giacomo;Toniolo, Gianluca;Albino, Martin;Severi, Mirko;Andreozzi, Patrizia;Tria, Giancarlo;Guerri, Annalisa;Berti, Debora;Marradi, Marco;Cicchi, Stefano;Richichi, Barbara
2023

Abstract

Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.
2023
8
776
782
Goal 3: Good health and well-being
Biagiotti, Giacomo; Toniolo, Gianluca; Albino, Martin; Severi, Mirko; Andreozzi, Patrizia; Marelli, Marcello; Kokot, Hana; Tria, Giancarlo; Guerri, Annalisa; Sangregorio, Claudio; Rojo, Javier; Berti, Debora; Marradi, Marco; Cicchi, Stefano; Urbančič, Iztok; van Kooyk, Yvette; Chiodo, Fabrizio; Richichi, Barbara
File in questo prodotto:
File Dimensione Formato  
NanoscaleHorizons2023.pdf

accesso aperto

Descrizione: Pdf editoriale
Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 1.46 MB
Formato Adobe PDF
1.46 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1309402
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact