The derangement of CSF circulation impacts the functions of the glymphatic-lymphatic system (G-Ls), which regulates solute trafficking and immune surveillance in the CNS. The G-Ls failure leads to the dysregulation of clearance of waste molecules in the brain and to an altered CNS immune response. The imaging features of dilated perivascular spaces imply the impairment of the G-Ls. We report on the case of a patient with primary progressive multiple sclerosis and dilatation of perivascular spaces, who transiently improved after CSF shunt diversions. The underlying mechanisms remain to be determined and at this stage, it is not possible to link CSF diversion to an effect on MS pathology. However, this observation provides the rationale to incentivize research in the largely unknown area of CSF dynamic disturbances on G-Ls failure and ultimately in neurodegeneration.

Case report: A multiple sclerosis patient with imaging features of glymphatic failure benefitted from CSF flow shunting / Scollato, Antonio; Lolli, Francesco; Lastrucci, Giancarlo; Repice, Anna; De Santis, Giuseppe; Nicoletti, Claudio; Porfirio, Berardino; Gallina, Pasquale. - In: FRONTIERS IN NEUROSCIENCE. - ISSN 1662-4548. - STAMPA. - 16:(2022), pp. 863117-863122. [10.3389/fnins.2022.863117]

Case report: A multiple sclerosis patient with imaging features of glymphatic failure benefitted from CSF flow shunting

Scollato, Antonio;Lolli, Francesco;Lastrucci, Giancarlo;Repice, Anna;Nicoletti, Claudio;Porfirio, Berardino;Gallina, Pasquale
2022

Abstract

The derangement of CSF circulation impacts the functions of the glymphatic-lymphatic system (G-Ls), which regulates solute trafficking and immune surveillance in the CNS. The G-Ls failure leads to the dysregulation of clearance of waste molecules in the brain and to an altered CNS immune response. The imaging features of dilated perivascular spaces imply the impairment of the G-Ls. We report on the case of a patient with primary progressive multiple sclerosis and dilatation of perivascular spaces, who transiently improved after CSF shunt diversions. The underlying mechanisms remain to be determined and at this stage, it is not possible to link CSF diversion to an effect on MS pathology. However, this observation provides the rationale to incentivize research in the largely unknown area of CSF dynamic disturbances on G-Ls failure and ultimately in neurodegeneration.
2022
16
863117
863122
Scollato, Antonio; Lolli, Francesco; Lastrucci, Giancarlo; Repice, Anna; De Santis, Giuseppe; Nicoletti, Claudio; Porfirio, Berardino; Gallina, Pasquale
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1311905
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