Blood vessels are the most important way for cancer cells to survive and diffuse in the body, metastasizing distant organs. During the process of tumor expansion, the neoplastic mass progressively induces modifications in the microenvironment due to its uncontrolled growth, generating a hypoxic and low pH milieu with high fluid pressure and low nutrients concentration. In such a particular condition, reactive oxygen species play a fundamental role, enhancing tumor proliferation and migration, inducing a glycolytic phenotype and promoting angiogenesis. Indeed, to reach new sources of oxygen and metabolites, highly aggressive cancer cells might produce a new abnormal network of vessels independently from endothelial cells, a process called vasculogenic mimicry. Even though many molecular markers and mechanisms, especially in gastric cancer, are still unclear, the formation of such intricate, leaky and abnormal vessel networks is closely associated with patients’ poor prognosis, and therefore finding new pharmaceutical solutions to be applied along with canonical chemotherapies in order to control and normalize the formation of such networks is urgent.

Gastric Cancer Vascularization and the Contribution of Reactive Oxygen Species / Biagioni, Alessio; Peri, Sara; Versienti, Giampaolo; Fiorillo, Claudia; Becatti, Matteo; Magnelli, Lucia; Papucci, Laura. - In: BIOMOLECULES. - ISSN 2218-273X. - ELETTRONICO. - 13:(2023), pp. 0-0. [10.3390/biom13060886]

Gastric Cancer Vascularization and the Contribution of Reactive Oxygen Species

Biagioni, Alessio
Writing – Original Draft Preparation
;
Peri, Sara;Versienti, Giampaolo;Fiorillo, Claudia;Becatti, Matteo;Magnelli, Lucia
Writing – Original Draft Preparation
;
Papucci, Laura
Writing – Review & Editing
2023

Abstract

Blood vessels are the most important way for cancer cells to survive and diffuse in the body, metastasizing distant organs. During the process of tumor expansion, the neoplastic mass progressively induces modifications in the microenvironment due to its uncontrolled growth, generating a hypoxic and low pH milieu with high fluid pressure and low nutrients concentration. In such a particular condition, reactive oxygen species play a fundamental role, enhancing tumor proliferation and migration, inducing a glycolytic phenotype and promoting angiogenesis. Indeed, to reach new sources of oxygen and metabolites, highly aggressive cancer cells might produce a new abnormal network of vessels independently from endothelial cells, a process called vasculogenic mimicry. Even though many molecular markers and mechanisms, especially in gastric cancer, are still unclear, the formation of such intricate, leaky and abnormal vessel networks is closely associated with patients’ poor prognosis, and therefore finding new pharmaceutical solutions to be applied along with canonical chemotherapies in order to control and normalize the formation of such networks is urgent.
2023
13
0
0
Biagioni, Alessio; Peri, Sara; Versienti, Giampaolo; Fiorillo, Claudia; Becatti, Matteo; Magnelli, Lucia; Papucci, Laura
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1312533
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