Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.

Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents / Petroni, Giulia; Galluzzi, Lorenzo. - In: ONCOIMMUNOLOGY. - ISSN 2162-402X. - ELETTRONICO. - 10:(2021), pp. 0-0. [10.1080/2162402X.2021.1889101]

Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents

Petroni, Giulia;Galluzzi, Lorenzo
2021

Abstract

Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.
2021
10
0
0
Petroni, Giulia; Galluzzi, Lorenzo
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1314459
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