At odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy.
Immunomodulation by targeted anticancer agents / Petroni, Giulia; Buqué, Aitziber; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo. - In: CANCER CELL. - ISSN 1535-6108. - ELETTRONICO. - 39:(2021), pp. 310-345. [10.1016/j.ccell.2020.11.009]
Immunomodulation by targeted anticancer agents
Petroni, Giulia;Galluzzi, Lorenzo
2021
Abstract
At odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy.
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