Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8(+) T cells.
Senescence Inflames the Pancreatic Tumor Microenvironment / Petroni, Giulia; Galluzzi, Lorenzo. - In: CELL REPORTS MEDICINE. - ISSN 2666-3791. - ELETTRONICO. - 1:(2020), pp. 0-0. [10.1016/j.xcrm.2020.100020]
Senescence Inflames the Pancreatic Tumor Microenvironment
Petroni, Giulia;Galluzzi, Lorenzo
2020
Abstract
Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8(+) T cells.
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