Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.
Caspase 2 and p53 Reunited in Tumor Control / Petroni, Giulia; Vitale, Ilio; Galluzzi, Lorenzo. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - ELETTRONICO. - 30:(2020), pp. 917-918. [10.1016/j.tcb.2020.09.001]
Caspase 2 and p53 Reunited in Tumor Control
Petroni, Giulia;Galluzzi, Lorenzo
2020
Abstract
Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.
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