Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the production of the energy load needed at critical times during development and in response to nutrient shortage. Autophagy is generally considered as a pro-survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy efficiency declines with age, thus contributing to many different pathophysiological conditions, such as cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Accordingly, it has been proposed that the maintenance of a proper autophagic activity contributes to the extension of the lifespan in different organisms. A better understanding of the interplay between autophagy and risk of age-related pathologies is important to propose nutritional and life-style habits favouring disease prevention as well as possible clinical applications aimed at promoting long-term health

Autophagy-related proteins: potential diagnostic and prognostic biomarkers of aging-related diseases / Bucciantini Monica; Leri Manuela; Stefani Massimo;. - In: AGEING RESEARCH REVIEWS. - ISSN 1568-1637. - ELETTRONICO. - (2023), pp. 0-0. [10.1016/j.arr.2023.101967]

Autophagy-related proteins: potential diagnostic and prognostic biomarkers of aging-related diseases.

Bucciantini Monica
;
Leri Manuela;Stefani Massimo
2023

Abstract

Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the production of the energy load needed at critical times during development and in response to nutrient shortage. Autophagy is generally considered as a pro-survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy efficiency declines with age, thus contributing to many different pathophysiological conditions, such as cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Accordingly, it has been proposed that the maintenance of a proper autophagic activity contributes to the extension of the lifespan in different organisms. A better understanding of the interplay between autophagy and risk of age-related pathologies is important to propose nutritional and life-style habits favouring disease prevention as well as possible clinical applications aimed at promoting long-term health
2023
0
0
Bucciantini Monica; Leri Manuela; Stefani Massimo;
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1314476
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