Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin stands out as promising combinatorial partner to improve the efficacy of chemotherapy in patients with colorectal cancer.
Targeting potassium channels and autophagy to defeat chemoresistance / Petroni, Giulia. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - ELETTRONICO. - 7:(2020), pp. 0-0. [10.1080/23723556.2020.1745038]
Targeting potassium channels and autophagy to defeat chemoresistance
Petroni, Giulia
2020
Abstract
Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin stands out as promising combinatorial partner to improve the efficacy of chemotherapy in patients with colorectal cancer.File | Dimensione | Formato | |
---|---|---|---|
Targeting potassium channels and autophagy to defeat chemoresistance.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
1.06 MB
Formato
Adobe PDF
|
1.06 MB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.