: NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.

The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis / Ghini, Veronica; Mannelli, Michele; Massai, Lara; Geri, Andrea; Zineddu, Stefano; Gamberi, Tania; Messori, Luigi; Turano, Paola. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 13:(2023), pp. 21629-21632. [10.1039/d3ra04032a]

The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

Ghini, Veronica;Mannelli, Michele;Massai, Lara;Geri, Andrea;Zineddu, Stefano;Gamberi, Tania;Messori, Luigi
;
Turano, Paola
2023

Abstract

: NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.
2023
13
21629
21632
Ghini, Veronica; Mannelli, Michele; Massai, Lara; Geri, Andrea; Zineddu, Stefano; Gamberi, Tania; Messori, Luigi; Turano, Paola
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1321191
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact