: NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.
The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis / Ghini, Veronica; Mannelli, Michele; Massai, Lara; Geri, Andrea; Zineddu, Stefano; Gamberi, Tania; Messori, Luigi; Turano, Paola. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 13:(2023), pp. 21629-21632. [10.1039/d3ra04032a]
The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
Ghini, Veronica;Mannelli, Michele;Massai, Lara;Geri, Andrea;Zineddu, Stefano;Gamberi, Tania;Messori, Luigi
;Turano, Paola
2023
Abstract
: NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.
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