Recent data suggest that the deleterious effect on general health and cognition of ε4 allele of Apolipoprotein E (ApoE) observed in the elderly population, may attenuate in extreme aging. This study aimed to describe the ApoE genotype distribution and its relationship with cognition in a group of nonagenarians living in the Mugello area, Italy. ApoE ε3 was the most prevalent genotype (76.3%). Results support that ApoE genotype no longer plays a role in the health condition of the oldest old, however, an interaction is detectable between ApoE polymorphism and cognitive performances at this extreme age.
Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the "Mugello study" / Gemma Lombardi, Silvia Pancani, Silvia Bagnoli, Federica Vannetti, Benedetta Nacmias, Sandro Sorbi, Francesca Cecchi, Claudio Macchi. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - ELETTRONICO. - (2023), pp. 0-0. [10.1007/s10072-023-07073-4]
Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the "Mugello study"
Gemma Lombardi;Silvia Bagnoli;Benedetta Nacmias;Sandro Sorbi;Francesca Cecchi;Claudio Macchi
2023
Abstract
Recent data suggest that the deleterious effect on general health and cognition of ε4 allele of Apolipoprotein E (ApoE) observed in the elderly population, may attenuate in extreme aging. This study aimed to describe the ApoE genotype distribution and its relationship with cognition in a group of nonagenarians living in the Mugello area, Italy. ApoE ε3 was the most prevalent genotype (76.3%). Results support that ApoE genotype no longer plays a role in the health condition of the oldest old, however, an interaction is detectable between ApoE polymorphism and cognitive performances at this extreme age.
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