Background: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. Conclusions: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.

Ulcer, gastric surgery and pancreatic cancer risk : an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4) / C. Bosetti; E. Lucenteforte; P. M. Bracci; E. Negri; R. E. Neale; H. A. Risch; S. H. Olson; S. Gallinger; A. B. Miller; H. B. Bueno de Mesquita; R. Talamini; J. Polesel; P. Ghadirian; P. A. Baghurst; W. Zatonski; E. Fontham; E. A. Holly; Y. T. Gao; H. Yu; R. C. Kurtz; M. Cotterchio; P. Maisonneuve; M. P. Zeegers; E. J. Duell; P. Boffetta; C. La Vecchia. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 24:(2013), pp. mdt336.2903-mdt336.2910. [10.1093/annonc/mdt336]

Ulcer, gastric surgery and pancreatic cancer risk : an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

E. Lucenteforte;
2013

Abstract

Background: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. Conclusions: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.
2013
24
2903
2910
C. Bosetti; E. Lucenteforte; P. M. Bracci; E. Negri; R. E. Neale; H. A. Risch; S. H. Olson; S. Gallinger; A. B. Miller; H. B. Bueno de Mesquita; R. Talamini; J. Polesel; P. Ghadirian; P. A. Baghurst; W. Zatonski; E. Fontham; E. A. Holly; Y. T. Gao; H. Yu; R. C. Kurtz; M. Cotterchio; P. Maisonneuve; M. P. Zeegers; E. J. Duell; P. Boffetta; C. La Vecchia
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1335932
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