Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis.

Alexandre, R Zlotta; Leslie, K Ballas; Niemierko, Andrzej; Lajkosz, Katherine; Kuk, Cynthia; Miranda, Gus; Drumm, Michael; Mari, Andrea; Thio, Ethan; Neil, E Fleshner; Girish, S Kulkarni; Michael A, S Jewett; Robert, G Bristow; Catton, Charles; Berlin, Alejandro; Srikala, S Sridhar; Schuckman, Anne; Adam, S Feldman; Wszolek, Matthew; Douglas, M Dahl; Richard, J Lee; Philip, J Saylor; M Dror Michaelson,; David, T Miyamoto; Zietman, Anthony; Shipley, William; Chung, Peter; Daneshmand, Siamak; Jason, A Efstathiou

doi:10.1016/S1470-2045(23)00170-5

Previous randomised controlled trials comparing bladder preservation with radical cystectomy for muscle-invasive bladder cancer closed due to insufficient accrual. Given that no further trials are foreseen, we aimed to use propensity scores to compare trimodality therapy (maximal transurethral resection of bladder tumour followed by concurrent chemoradiation) with radical cystectomy.

Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis / Alexandre R Zlotta, Leslie K Ballas, Andrzej Niemierko, Katherine Lajkosz, Cynthia Kuk, Gus Miranda, Michael Drumm, Andrea Mari, Ethan Thio, Neil E Fleshner, Girish S Kulkarni, Michael A S Jewett, Robert G Bristow, Charles Catton, Alejandro Berlin, Srikala S Sridhar, Anne Schuckman, Adam S Feldman, Matthew Wszolek, Douglas M Dahl, Richard J Lee, Philip J Saylor, M Dror Michaelson, David T Miyamoto, Anthony Zietman, William Shipley, Peter Chung, Siamak Daneshmand, Jason A Efstathiou. - In: THE LANCET ONCOLOGY. - ISSN 1474-5488. - ELETTRONICO. - 24:(2023), pp. 669-681. [10.1016/S1470-2045(23)00170-5]