The current diagnostic standard for bullous pemphigoid (BP) provides the linear deposition of IgG autoantibodies and/or C3 fraction of the complement against structural proteins of the dermo-epidermal junction (DEJ) at direct immunofluorescence (DIF) microscopy. Instead, the significance of linear IgM junctional staining in cutaneous immunopathology is not clear denoting many known dermatological disorders. Herein is reported a case of BP characterized by the finding of IgM linear deposits at the DEJ along with non-classical clinical features.
Linear deposits of IgM along the dermo-epidermal junction possibly associated with non-classical clinical features in bullous pemphigoid / Mariotti E.B.; Corra A.; Aimo C.; RuffodiCalabria V.; Cavazza G.; Quintarelli L.; Verdelli A.; Mariotti F.; DiZenzo G.; Caproni M.. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 1468-3083. - ELETTRONICO. - (2023), pp. 0-0. [10.1111/jdv.19515]
Linear deposits of IgM along the dermo-epidermal junction possibly associated with non-classical clinical features in bullous pemphigoid
Mariotti E. B.
;Aimo C.;Cavazza G.;Quintarelli L.;Verdelli A.;Caproni M.
2023
Abstract
The current diagnostic standard for bullous pemphigoid (BP) provides the linear deposition of IgG autoantibodies and/or C3 fraction of the complement against structural proteins of the dermo-epidermal junction (DEJ) at direct immunofluorescence (DIF) microscopy. Instead, the significance of linear IgM junctional staining in cutaneous immunopathology is not clear denoting many known dermatological disorders. Herein is reported a case of BP characterized by the finding of IgM linear deposits at the DEJ along with non-classical clinical features.
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Acad Dermatol Venereol - 2023 - Mariotti - Linear deposits of IgM along the dermo%E2%80%90epidermal junction possibly associated.pdf
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