Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging / Brero F.; Calzolari P.; Albino M.; Antoccia A.; Arosio P.; Avolio M.; Berardinelli F.; Bettega D.; Ciocca M.; Facoetti A.; Gallo S.; Groppi F.; Innocenti C.; Laurenzana A.; Lenardi C.; Locarno S.; Manenti S.; Marchesini R.; Mariani M.; Orsini F.; Pignoli E.; Sangregorio C.; Scavone F.; Veronese I.; Lascialfari A.. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - ELETTRONICO. - (2023), pp. 126.0-126.0. [10.1393/ncc/i2023-23126-6]
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging
Albino M.;Arosio P.;Innocenti C.;Laurenzana A.;Sangregorio C.;Scavone F.;Lascialfari A.
2023
Abstract
Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
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