Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging / Brero F., Calzolari P., Albino M., Antoccia A., Arosio P., Avolio M., Berardinelli F., Bettega D., Ciocca M., Facoetti A., Gallo S., Groppi F., Innocenti C., Laurenzana A., Lenardi C., Locarno S., Manenti S., Marchesini R., Mariani M., Orsini F., et al.. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - ELETTRONICO. - (2023), pp. 126.0-126.0. [10.1393/ncc/i2023-23126-6]
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging
Albino M.;Arosio P.;Innocenti C.;Laurenzana A.;Sangregorio C.;Scavone F.;Lascialfari A.
2023
Abstract
Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
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