A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation.
An Epiisopicropodophyllin Aza Analogue via Palladium-Catalyzed Pseudo-Domino Cyclization / Poli G; Giambastiani G. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 67:(2002), pp. 9456-9459. [10.1021/jo026068]
An Epiisopicropodophyllin Aza Analogue via Palladium-Catalyzed Pseudo-Domino Cyclization
Giambastiani G
2002
Abstract
A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation.
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