This is the study protocol of a single-center, randomized controlled single-blind trial comparing treadmill training (TT) with augmented virtual reality (AVR) application with conventional TT in II-III stage PD patients suffering from gait disturbances. The primary aim of this study is to compare the effects on gait performances of TT + AVR versus TT alone in II-III stage PD patients with gait disturbance. Secondary aims are to assess the effects on balance, gait parameters and other motor and non-motor symptoms, and patient's satisfaction and adherence to the treatment. As an exploratory aim, the study attempts to identify biomarkers of neuroplasticity detecting changes in Neurofilament Light Chain concentration T0-T1 and to identify prognostic biomarkers associated to blood-derived Extracellular Vesicles. This study will provide data on the possible superiority of AVR-associated treadmill training (TT) over conventional TT in improving gait and other motor and non-motor symptoms in persons with PD and gait disturbances. The results of the exploratory analysis could add information in the field of biomarker research in PD rehabilitation

Comparing the effects of augmented virtual reality treadmill training versus conventional treadmill training in patients with stage II-III Parkinson's disease: the VIRTREAD-PD randomized controlled trial protocol / Baccini M, Gualerzi A, Pancani S, Campagnini S, Doronzio S, Longo D, Maselli A, Cherubini G, Piazzini M, Ciapetti T, Polito C, Pinna S, De Santis C, Bedoni M, Macchi C, Ramat S, Cecchi F.. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - ELETTRONICO. - 15:(2024), pp. 0-0. [10.3389/fneur.2024.1338609]

Comparing the effects of augmented virtual reality treadmill training versus conventional treadmill training in patients with stage II-III Parkinson's disease: the VIRTREAD-PD randomized controlled trial protocol

Campagnini S;Doronzio S;Longo D;Maselli A;Cecchi F.
Writing – Review & Editing
2024

Abstract

This is the study protocol of a single-center, randomized controlled single-blind trial comparing treadmill training (TT) with augmented virtual reality (AVR) application with conventional TT in II-III stage PD patients suffering from gait disturbances. The primary aim of this study is to compare the effects on gait performances of TT + AVR versus TT alone in II-III stage PD patients with gait disturbance. Secondary aims are to assess the effects on balance, gait parameters and other motor and non-motor symptoms, and patient's satisfaction and adherence to the treatment. As an exploratory aim, the study attempts to identify biomarkers of neuroplasticity detecting changes in Neurofilament Light Chain concentration T0-T1 and to identify prognostic biomarkers associated to blood-derived Extracellular Vesicles. This study will provide data on the possible superiority of AVR-associated treadmill training (TT) over conventional TT in improving gait and other motor and non-motor symptoms in persons with PD and gait disturbances. The results of the exploratory analysis could add information in the field of biomarker research in PD rehabilitation
2024
15
0
0
Baccini M, Gualerzi A, Pancani S, Campagnini S, Doronzio S, Longo D, Maselli A, Cherubini G, Piazzini M, Ciapetti T, Polito C, Pinna S, De Santis C, Bedoni M, Macchi C, Ramat S, Cecchi F.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1352932
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