Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature, revealed by the NMR analysis of a cohort of >500 patients sampled during various waves of COVID-19 infection, corresponding to the spread of different variants, and having different vaccination status. This composite signature highlights common traits of the SARS-CoV-2 infection. The most dysregulated molecules display concentration trends that scale with disease severity and might serve as prognostic markers for fatal events. Metabolomics evidence is then used as input data for a sex-specific multi-organ metabolic model. This reconstruction provides a comprehensive view of the impact of COVID-19 on the entire human metabolism. The human (male and female) metabolic network is strongly impacted by the disease to an extent dictated by its severity. A marked metabolic reprogramming at the level of many organs indicates an increase in the generic energetic demand of the organism following infection. Sex-specific modulation of immune response is also suggested.

COVID-19: A complex disease with a unique metabolic signature / Ghini, Veronica; Vieri, Walter; Celli, Tommaso; Pecchioli, Valentina; Boccia, Nunzia; Alonso-Vásquez, Tania; Pelagatti, Lorenzo; Fondi, Marco; Luchinat, Claudio; Bertini, Laura; Vannucchi, Vieri; Landini, Giancarlo; Turano, Paola. - In: PLOS PATHOGENS. - ISSN 1553-7374. - ELETTRONICO. - 19:(2023), pp. e1011787.0-e1011787.0. [10.1371/journal.ppat.1011787]

COVID-19: A complex disease with a unique metabolic signature

Ghini, Veronica;Vieri, Walter;Celli, Tommaso;Pecchioli, Valentina;Pelagatti, Lorenzo;Fondi, Marco;Luchinat, Claudio;Bertini, Laura;Vannucchi, Vieri;Landini, Giancarlo;Turano, Paola
2023

Abstract

Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature, revealed by the NMR analysis of a cohort of >500 patients sampled during various waves of COVID-19 infection, corresponding to the spread of different variants, and having different vaccination status. This composite signature highlights common traits of the SARS-CoV-2 infection. The most dysregulated molecules display concentration trends that scale with disease severity and might serve as prognostic markers for fatal events. Metabolomics evidence is then used as input data for a sex-specific multi-organ metabolic model. This reconstruction provides a comprehensive view of the impact of COVID-19 on the entire human metabolism. The human (male and female) metabolic network is strongly impacted by the disease to an extent dictated by its severity. A marked metabolic reprogramming at the level of many organs indicates an increase in the generic energetic demand of the organism following infection. Sex-specific modulation of immune response is also suggested.
2023
19
0
0
Goal 3: Good health and well-being
Ghini, Veronica; Vieri, Walter; Celli, Tommaso; Pecchioli, Valentina; Boccia, Nunzia; Alonso-Vásquez, Tania; Pelagatti, Lorenzo; Fondi, Marco; Luchinat, Claudio; Bertini, Laura; Vannucchi, Vieri; Landini, Giancarlo; Turano, Paola
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1353506
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