Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease / Amedei, Amedeo; Pimpinelli, Nicola; Grassi, Alessia; Bella, Chiara Della; Niccolai, Elena; Brancati, Simona; Benagiano, Marisa; D'Elios, Sofia; Bosi, Alberto; D'Elios, Mario M. - In: AUTOIMMUNITY HIGHLIGHTS. - ISSN 2038-0305. - ELETTRONICO. - 5:(2014), pp. 0-0. [10.1007/s13317-013-0054-7]
Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
Amedei, Amedeo;Pimpinelli, Nicola;Grassi, Alessia;Bella, Chiara Della;Niccolai, Elena;Brancati, Simona;Benagiano, Marisa;Bosi, Alberto;D'Elios, Mario M
2014
Abstract
Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.