Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis / Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Bonavita, Simona; Buscarinu, Maria; Calabrese, Massimiliano; Cavalla, Paola; Cellerino, Maria; Cordioli, Cinzia; Dattola, Vincenzo; De Biase, Stefano; De Meo, Ermelinda; Fantozzi, Roberta; Gallo, Antonio; Iasevoli, Luigi; Karabudak, Rana; Landi, Doriana; Lorefice, Lorena; Moiola, Lucia; Ragonese, Paolo; Ruscica, Francesca; Sen, Sedat; Sinisi, Leonardo; Signoriello, Elisabetta; Toscano, Simona; Verrengia, Elena; Siva, Aksel; Masciulli, Camilla; Sormani, Maria Pia; Amato, Maria Pia. - In: MULTIPLE SCLEROSIS. - ISSN 1477-0970. - ELETTRONICO. - (2024), pp. 0-0. [10.1177/13524585241232266]

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Aprea, Maria Grazia;Portaccio, Emilio;Ballerini, Chiara;De Meo, Ermelinda;Gallo, Antonio;Masciulli, Camilla;Amato, Maria Pia
2024

Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.
2024
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0
Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Bonavita, Simona; Buscarinu, Maria; Calabrese, Massimiliano; Cavalla, Paola; Cellerino, Maria; Cordioli, Cinzia; Dattola, Vincenzo; De Biase, Stefano; De Meo, Ermelinda; Fantozzi, Roberta; Gallo, Antonio; Iasevoli, Luigi; Karabudak, Rana; Landi, Doriana; Lorefice, Lorena; Moiola, Lucia; Ragonese, Paolo; Ruscica, Francesca; Sen, Sedat; Sinisi, Leonardo; Signoriello, Elisabetta; Toscano, Simona; Verrengia, Elena; Siva, Aksel; Masciulli, Camilla; Sormani, Maria Pia; Amato, Maria Pia
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1356532
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