The response to mRNA vaccines against SARS-CoV-2 has been shown to be better in adolescents and young adults than adults.1 Kidney transplant recipients (KTRs) show a suboptimal response to mRNA vaccines compared with the general population because of immunosuppressive therapy,2 and a third dose is suggested to boost immune response in KTRs.3 Neutralizing antibodies (anti–receptor binding domain [anti-RBD]) were demonstrated to predict protection against symptomatic infection.4 However, reports on adolescent and young adult KTRs are scarce and mostly based on total antispike (anti-S) immunoglobulin G (IgG) detection.5 We report the response profile in this population completing the vaccine schedule.
Response to Third Dose of Vaccine Against SARS-CoV-2 in Adolescent and Young Adult Kidney Transplant Recipients / Cirillo L.; Citera F.; Mazzierli T.; Becherucci F.; Terlizzi V.; Lodi L.; Buti E.; Romagnani P.. - In: TRANSPLANTATION. - ISSN 0041-1337. - ELETTRONICO. - 106:(2022), pp. 386-387. [10.1097/TP.0000000000004199]
Response to Third Dose of Vaccine Against SARS-CoV-2 in Adolescent and Young Adult Kidney Transplant Recipients
Cirillo L.;Citera F.;Mazzierli T.;Terlizzi V.;Lodi L.;Buti E.;Romagnani P.
2022
Abstract
The response to mRNA vaccines against SARS-CoV-2 has been shown to be better in adolescents and young adults than adults.1 Kidney transplant recipients (KTRs) show a suboptimal response to mRNA vaccines compared with the general population because of immunosuppressive therapy,2 and a third dose is suggested to boost immune response in KTRs.3 Neutralizing antibodies (anti–receptor binding domain [anti-RBD]) were demonstrated to predict protection against symptomatic infection.4 However, reports on adolescent and young adult KTRs are scarce and mostly based on total antispike (anti-S) immunoglobulin G (IgG) detection.5 We report the response profile in this population completing the vaccine schedule.
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