Kirsten rat sarcoma viral oncogene (KRAS) G12C was identified to be a drug target and a predictor of response to the novel AMG510 drug. We showed that KRAS G12C-mutated colorectal cancer has specific clinicopathologic features and worse outcome compared to other KRAS-mutated cases. The knowledge of such distinctive traits of KRAS G12C mutations might be crucial to future translational research studies and clinical trial design.

KRAS G12C Metastatic Colorectal Cancer: Specific Features of a New Emerging Target Population / Schirripa M., Nappo F., Cremolini C., Salvatore L., Rossini D., Bensi M., Businello G., Pietrantonio F., Randon G., Fuca G., Boccaccino A., Bergamo F., Lonardi S., Dei Tos A.P., Fassan M., Loupakis F.. - In: CLINICAL COLORECTAL CANCER. - ISSN 1533-0028. - ELETTRONICO. - 19:(2020), pp. 219-225. [10.1016/j.clcc.2020.04.009]

KRAS G12C Metastatic Colorectal Cancer: Specific Features of a New Emerging Target Population

Rossini D.;
2020

Abstract

Kirsten rat sarcoma viral oncogene (KRAS) G12C was identified to be a drug target and a predictor of response to the novel AMG510 drug. We showed that KRAS G12C-mutated colorectal cancer has specific clinicopathologic features and worse outcome compared to other KRAS-mutated cases. The knowledge of such distinctive traits of KRAS G12C mutations might be crucial to future translational research studies and clinical trial design.
2020
19
219
225
Goal 3: Good health and well-being
Schirripa M.; Nappo F.; Cremolini C.; Salvatore L.; Rossini D.; Bensi M.; Businello G.; Pietrantonio F.; Randon G.; Fuca G.; Boccaccino A.; Bergamo F....espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1356780
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