Neuroimmunomodulation is the capacity of the nervous system to regulate immune processes. The existence of neurotransmitter receptors in immune cells enables this phenomenon to take place. Neuronal mediators possess the capacity to direct and control several occurrences during the wound healing process. Nitric oxide (NO) functions as a neuromodulator, playing a crucial role in the regulation of vascular tone and blood pressure with antimicrobial properties. Photodynamic therapy has been shown to augment the function of immune cells involved in the healing process of venous leg ulcers. Nitric oxide can be secreted into the extracellular environment by these cells. In lesions treated with PDT, the synthesis of iNOs (the enzyme that releases NO) increased, as demonstrated by the experimental results. Therefore the significance of PDT in enhancing the clinical condition of the lesion is thus highlighted.
Neuroimmunomodulatory Effect of NO on Chronic Wound Healing After Photodynamic Therapy / Patrizia Nardini, Lorenzo Notari, Miriam Magazzini, Bianca Mariani, Federico Rossi, Sofia Rossi, Elisabeth Van Aardt; Katarzyna Marszalek, Vieri Grandi, Alessandro Corsi, Nicola Pimpinelli, Stefano Bacci. - In: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. - ISSN 1572-1000. - STAMPA. - 47:(2024), pp. 104078-104081. [10.1016/j.pdpdt.2024.104078]
Neuroimmunomodulatory Effect of NO on Chronic Wound Healing After Photodynamic Therapy
Patrizia NardiniMembro del Collaboration Group
;Lorenzo NotariConceptualization
;Vieri GrandiMembro del Collaboration Group
;Nicola PimpinelliMembro del Collaboration Group
;Stefano Bacci
Conceptualization
2024
Abstract
Neuroimmunomodulation is the capacity of the nervous system to regulate immune processes. The existence of neurotransmitter receptors in immune cells enables this phenomenon to take place. Neuronal mediators possess the capacity to direct and control several occurrences during the wound healing process. Nitric oxide (NO) functions as a neuromodulator, playing a crucial role in the regulation of vascular tone and blood pressure with antimicrobial properties. Photodynamic therapy has been shown to augment the function of immune cells involved in the healing process of venous leg ulcers. Nitric oxide can be secreted into the extracellular environment by these cells. In lesions treated with PDT, the synthesis of iNOs (the enzyme that releases NO) increased, as demonstrated by the experimental results. Therefore the significance of PDT in enhancing the clinical condition of the lesion is thus highlighted.File | Dimensione | Formato | |
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