Objectives Polycythemia vera (PV) is an acquired clonal hematopoietic stem cell disorder characterized by the overproduction of red blood cells. It has long been underlined that there are differences in treatment patterns in routine practice. Therapeutic strategies have also expanded, and in recent years the JAK1/JAK2 inhibitor ruxolitinib has emerged as a second-line therapeutic option in patients who are intolerant to or resistant to hydroxyurea. Determining the impact of changes on practice patterns is of interest, especially for aspects that lack detailed guidance for management. Methods To gain insights into treatment patterns by clinicians treating patients with PV in Italy, we carried out a survey of 60 hematologists and transfusion specialists. The questions covered: treatment of low-risk patients, definition of significant leukocytosis, splenomegaly and excessive phlebotomies, resistance/intolerance to hydroxyurea, use of ruxolitinib, cytoreductive therapy, and vaccines. Results In general, the results of the survey indicate that there is a large heterogeneity in management of patients with PV across these areas. Conclusions While helping to provide greater understanding of treatment patterns for patients with PV in Italy, our survey highlights the need for additional clinical studies to obtain more precise guidance for the routine care of patients with PV.
Management of polycythemia vera: A survey of treatment patterns in Italy / Palumbo, Giuseppe Alberto; Breccia, Massimo; Baratè, Claudia; Bonifacio, Massimiliano; Elli, Elena Maria; Iurlo, Alessandra; Pugliese, Novella; Rossi, Elena; Guglielmelli, Paola; Palandri, Francesca. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - ELETTRONICO. - 110:(2023), pp. 161-167. [10.1111/ejh.13889]
Management of polycythemia vera: A survey of treatment patterns in Italy
Guglielmelli, Paola;
2023
Abstract
Objectives Polycythemia vera (PV) is an acquired clonal hematopoietic stem cell disorder characterized by the overproduction of red blood cells. It has long been underlined that there are differences in treatment patterns in routine practice. Therapeutic strategies have also expanded, and in recent years the JAK1/JAK2 inhibitor ruxolitinib has emerged as a second-line therapeutic option in patients who are intolerant to or resistant to hydroxyurea. Determining the impact of changes on practice patterns is of interest, especially for aspects that lack detailed guidance for management. Methods To gain insights into treatment patterns by clinicians treating patients with PV in Italy, we carried out a survey of 60 hematologists and transfusion specialists. The questions covered: treatment of low-risk patients, definition of significant leukocytosis, splenomegaly and excessive phlebotomies, resistance/intolerance to hydroxyurea, use of ruxolitinib, cytoreductive therapy, and vaccines. Results In general, the results of the survey indicate that there is a large heterogeneity in management of patients with PV across these areas. Conclusions While helping to provide greater understanding of treatment patterns for patients with PV in Italy, our survey highlights the need for additional clinical studies to obtain more precise guidance for the routine care of patients with PV.File | Dimensione | Formato | |
---|---|---|---|
EJH-110-161.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
1.58 MB
Formato
Adobe PDF
|
1.58 MB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.