: Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non-small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.

Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy / Petroni, Giulia; Pillozzi, Serena; Antonuzzo, Lorenzo. - In: CANCER RESEARCH. - ISSN 0008-5472. - ELETTRONICO. - 84:(2024), pp. 1199-1209. [10.1158/0008-5472.can-23-3325]

Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy

Petroni, Giulia;Pillozzi, Serena;Antonuzzo, Lorenzo
2024

Abstract

: Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non-small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
2024
84
1199
1209
Petroni, Giulia; Pillozzi, Serena; Antonuzzo, Lorenzo
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Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 2.54 MB
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2.54 MB Adobe PDF

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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1357648
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