Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.

Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4and Fe3O4metal cores / Psimadas, D; Baldi, G; Ravagli, C; Comes Franchini, M; Locatelli, E; Innocenti, C; Sangregorio, C; Loudos, G. - In: NANOTECHNOLOGY. - ISSN 0957-4484. - ELETTRONICO. - 25:(2014), pp. 025101.0-025101.0. [10.1088/0957-4484/25/2/025101]

Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4and Fe3O4metal cores

Innocenti, C;
2014

Abstract

Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.
2014
25
0
0
Goal 3: Good health and well-being
Psimadas, D; Baldi, G; Ravagli, C; Comes Franchini, M; Locatelli, E; Innocenti, C; Sangregorio, C; Loudos, G
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1358361
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