Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of both acute and delayed reactions. In addition, procedures for management of BA-induced reactions, including preventive and diagnostic work-up, are provided. Lastly, this article summarizes the current knowledge of desensitization to several widely used monoclonal antibodies.
Hypersensitivity Reactions to Biologic Agents / Vultaggio, Alessandra; Castells, Mariana C.. - In: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. - ISSN 0889-8561. - ELETTRONICO. - 34:(2014), pp. 615-632. [10.1016/j.iac.2014.04.008]
Hypersensitivity Reactions to Biologic Agents
Vultaggio, Alessandra;
2014
Abstract
Biologic agents (BAs) are important therapeutic tools; their use has rapidly expanded and they are used in oncology, immunology, and inflammatory diseases. Their use may be limited, however, by adverse drug reactions. This article reviews the current literature on clinical presentation and pathogenic mechanisms of both acute and delayed reactions. In addition, procedures for management of BA-induced reactions, including preventive and diagnostic work-up, are provided. Lastly, this article summarizes the current knowledge of desensitization to several widely used monoclonal antibodies.
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