(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.

Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21 / Cantini, Francesca; Giannì, Paola; Bobone, Sara; Troiano, Cassandra; van Ingen, Hugo; Massoud, Renato; Perini, Nicoletta; Migliore, Luciana; Savarin, Philippe; Sanders, Charles; Stella, Lorenzo; Sette, Marco. - In: MEMBRANES. - ISSN 2077-0375. - ELETTRONICO. - 13:(2023), pp. 365-377. [10.3390/membranes13030365]

Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21

Cantini, Francesca
Conceptualization
;
2023

Abstract

(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.
2023
13
365
377
Cantini, Francesca; Giannì, Paola; Bobone, Sara; Troiano, Cassandra; van Ingen, Hugo; Massoud, Renato; Perini, Nicoletta; Migliore, Luciana; Savarin, ...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1364972
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