Background Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, risk factors for CRE BSI were determined by comparison with two control groups: patients with carbapenem-susceptible Enterobacterales (CSE) BSI, and patients without Enterobacterales infection (uninfected patients).Methods A multicentre, case-control-control study was nested in a European prospective cohort study on CRE (EURECA). CRE BSI:CSE BSI matching was 1:1, CRE BSI:Uninfected patients matching was 1:3, based on hospital, ward and length of stay. Conditional logistic regression was applied.Results From March 2016 to November 2018, 73 CRE BSIs, 73 CSE BSIs and 219 uninfected patients were included from 18 European hospitals. For CRE versus CSE BSI, previous CRE colonization/infection [incidence rate ratio (IRR) 7.32; 95% CI 1.65-32.38) increased the risk. For CRE versus uninfected controls, independent risk factors included: older age (IRR 1.03; 95% CI 1.01-1.06), patient referral (long-term care facility: IRR 7.19; 95% CI 1.51-34.24; acute care hospital: IRR 5.26; 95% CI 1.61-17.11), previous colonization/infection with other MDR organisms (MDROs) (IRR 9.71; 95% CI 2.33-40.56), haemodialysis (IRR 8.59; 95% CI 1.82-40.53), invasive procedures (IRR 5.66; 95% CI 2.11-15.16), and beta-lactam/beta-lactamase inhibitor combinations (IRR 3.92; 95% CI 1.68-9.13) or third/fourth generation cephalosporin (IRR 2.75; 95% CI 1.06-7.11) exposure within 3 months before enrolment.Conclusions Evidence of previous CRE colonization/infection was a major risk factor for carbapenem resistance among Enterobacterales BSI. Compared with uninfected patients, evidence of previous MDRO colonization/infection and healthcare exposure were important risk factors for CRE BSI. Targeted screening, infection prevention and antimicrobial stewardship should focus on these high-risk patients.
Risk factors for bloodstream infections due to carbapenem-resistant Enterobacterales: a nested case-control-control study / Zhou, Hongyu; Buetti, Niccolò; Pérez-Galera, Salvador; Bravo-Ferrer, Jose; Gutiérrez-Gutiérrez, Belén; Paniagua-García, María; Feifel, Jan; Sauser, Julien; Kostyanev, Tomi; Canton, Rafael; Tan, Lionel K; Basoulis, Dimitris; Pintado, Vicente; Roilides, Emmanuel; Dragovac, Gorana; Torre-Cisneros, Julian; Mediç, Deana; Akova, Murat; Goossens, Herman; Bonten, Marc; Harbarth, Stephan; Rodriguez-Baño, Jesus; De Kraker, Marlieke E A; null, null; Sojo-Dorado, Jesus; de la Serna, Almudena; Monteau, Sophie; Palomo, Virginia; Soriano, Elena; Gutiérrez, David; Moreno, Elisa; Palacios, Zaira; Morales, Isabel; Maldonado, Natalia; Reguera, Jose Maria; de Santis, Lucia Valiente; Ciezar, Antonio Plata; Mesa, Juan Diego Ruiz; Diaz, Beatriz Sobrino; Gomez, Ignacio Marquez; Camacho, Ines Perez; Palop, Begoña; Torre-Cisneros, Julian; Cano, Angela; Frutos-Adame, Azahara; Guzman-Puche, Julia; Gracia-Ahufinger, Irene; Perez-Nadales, Elena; Torre-Gimenez, Julian; Pyrpasopoulou, Athina; Iosifidis, Elias; Chorafa, Elsa; Carevic, Biljana; Jovanovic, Snezana; Radovanovic, Ivana; Petrovic, Sladjana; Cvetkovi, Slavica; Radulovic, Lili; Melentijevic, Srdjan-Sanja; Miljkovic, Natasa; Perucica, Ana; Kirakli, Cenk; Bicmen, Can; Senol, Gunes; Shaw, Evelyn; Tubau, Fe; Camara, Jordi; Gumucio, Victor Daniel; Daikos, George L; Deliolanis, John; Falagas, Matthew E; Ch. Pitiriga, Vassiliki; Triarides, Nikolaos; Argiti, Efstathia; Legakis, Nikolaos J; Margarita, Kyriakidou; Gijón-Cordero, Desirée; Ruiz-Garbajosa, Patricia; Suarez, Amaya; Bartoloni, Alessandro; Rossolini, Gian Maria; Florescu, Simin-Aysel; Nica, Maria; Benea, Serban; Talapan, Daniela; Hristea, Adriana; Maričić, Sanja Prijić; Jovetic, Anita; Milenkovic, Marija Zivanovic; Asensio, Angel; Caballero, Mireia Cantero; Ramírez, Lina M Parra; Ruiz-Antoran, Belen; Layunta-Acero, Rocio; Ruiz-Antoran, Belen; Korten, Volkan; Bilgin, Hüseyin; Hasdemir, Ufuk; Dalekos, George N; Stefos, Aggelos; Petinaki, Efthymia; Spyridis, Nikolaos; Michos, Athanasios; De Rosa, Francesco Giuseppe; Cavallo, Rossana; Petrosillo, Nicola; Dicaro, Antonio; Viale, Pierluigi; Landini, Maria Paola; degli Atti, Marta Luisa Ciofi; Masanovic, Mileva; Matkovic, Dusan; Satic, Dragan; Lopicic, Milena; Tsiodras, Sotirios; Zerva, Loukia; Blasi, Francesco; Di Pasquale, Marta; Arghittu, Milena; Viscoli, Claudio; Giacobbe, Daniele Roberto; Marchese, Anna; Vata, Andrei; Dorneanu, Olivia; Kapisyzi, Perlat; Tafaj, Silva; Vince, Adriana; Andrasevic, Arjana Tambic; Butic, Iva; Tsigou, Evdoxia; Gavala, Alexandra; Biniari, Theodora; Maltezos, Efstratios; Komnos, Apostolos; Karagiannis, Spyros; Tsalakou, Maria; Voulgaridi, Ioanna; Gogos, Charalampos; Spiliopoulou, Iris; Franzetti, Fabio; Rimoldi, Sara; Antonelli, Massimo; De Pascale, Gennaro; Di Gravio, Valentina; Spanu, Teresa; Lupse, Mihaela; Flonta, Mirela; Corneci, Dan; Buzea, Mariana; Tomescu, Dana; Marcu, Alexandra; Ghita, Camelia; Georgescu, Anca; Azamfirei, Leonard; Székely, Edit; Mitrović, Goran; Bukarica, Ljiljana; Vitorovic, Teodora; Krstić, Nataša Lukić; Mitrovic, Goran; Kocic, Branislava; Dinic, Marina; Raka, Lul; Kurti, Arsim; Díaz-Pollán, Beatriz; Loeches, Belen; López, Jose Ramón Arribas; Sabater, Julia Origüen; Chaves, Fernando; Muñoz, Patricia; Azap, Alpay; Karahan, Ceren; Sancak, Banu; Sahin, Arife; Akalin, Halis; Ozakin, Cüneyt. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 79:(2024), pp. 2132-2141. [10.1093/jac/dkae157]
Risk factors for bloodstream infections due to carbapenem-resistant Enterobacterales: a nested case-control-control study
Bartoloni, Alessandro;Rossolini, Gian Maria;Antonelli, Massimo;
2024
Abstract
Background Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, risk factors for CRE BSI were determined by comparison with two control groups: patients with carbapenem-susceptible Enterobacterales (CSE) BSI, and patients without Enterobacterales infection (uninfected patients).Methods A multicentre, case-control-control study was nested in a European prospective cohort study on CRE (EURECA). CRE BSI:CSE BSI matching was 1:1, CRE BSI:Uninfected patients matching was 1:3, based on hospital, ward and length of stay. Conditional logistic regression was applied.Results From March 2016 to November 2018, 73 CRE BSIs, 73 CSE BSIs and 219 uninfected patients were included from 18 European hospitals. For CRE versus CSE BSI, previous CRE colonization/infection [incidence rate ratio (IRR) 7.32; 95% CI 1.65-32.38) increased the risk. For CRE versus uninfected controls, independent risk factors included: older age (IRR 1.03; 95% CI 1.01-1.06), patient referral (long-term care facility: IRR 7.19; 95% CI 1.51-34.24; acute care hospital: IRR 5.26; 95% CI 1.61-17.11), previous colonization/infection with other MDR organisms (MDROs) (IRR 9.71; 95% CI 2.33-40.56), haemodialysis (IRR 8.59; 95% CI 1.82-40.53), invasive procedures (IRR 5.66; 95% CI 2.11-15.16), and beta-lactam/beta-lactamase inhibitor combinations (IRR 3.92; 95% CI 1.68-9.13) or third/fourth generation cephalosporin (IRR 2.75; 95% CI 1.06-7.11) exposure within 3 months before enrolment.Conclusions Evidence of previous CRE colonization/infection was a major risk factor for carbapenem resistance among Enterobacterales BSI. Compared with uninfected patients, evidence of previous MDRO colonization/infection and healthcare exposure were important risk factors for CRE BSI. Targeted screening, infection prevention and antimicrobial stewardship should focus on these high-risk patients.
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