Background: The diagnostic and prognostic impact of traction bronchiectasis on high resolution CT scan (HRCT) in patients suspected to have idiopathic pulmonary fibrosis (IPF) is increasing significantly.Main body: Recent data demonstrated that cysts in honeycombing areas are covered by epithelium expressing bronchiolar markers. In IPF bronchiolization is the final consequence of a variety of pathogenic events starting from alveolar stem cell exhaustion, and ending in a abnormal/dysplastic proliferation of bronchiolar epithelium. CT scan features of traction bronchiectasis and honeycombing should be interpreted under the light of these new pathogenetic and morphologic considerations.Short conclusion: We suggest that in IPF subjects traction bronchiectasis and honeycombing -now defined as distinct entities on HRCT scan-are actually diverse aspects of a continuous spectrum of lung remodeling.
From "traction bronchiectasis" to honeycombing in idiopathic pulmonary fibrosis: A spectrum of bronchiolar remodeling also in radiology? / Piciucchi, Sara; Tomassetti, Sara; Ravaglia, Claudia; Gurioli, Christian; Gurioli, Carlo; Dubini, Alessandra; Carloni, Angelo; Chilosi, Marco; Colby, Thomas V; Poletti, Venerino. - In: BMC PULMONARY MEDICINE. - ISSN 1471-2466. - ELETTRONICO. - 16:(2016), pp. 87.0-87.0. [10.1186/s12890-016-0245-x]
From "traction bronchiectasis" to honeycombing in idiopathic pulmonary fibrosis: A spectrum of bronchiolar remodeling also in radiology?
Tomassetti, Sara;Dubini, Alessandra;Poletti, Venerino
2016
Abstract
Background: The diagnostic and prognostic impact of traction bronchiectasis on high resolution CT scan (HRCT) in patients suspected to have idiopathic pulmonary fibrosis (IPF) is increasing significantly.Main body: Recent data demonstrated that cysts in honeycombing areas are covered by epithelium expressing bronchiolar markers. In IPF bronchiolization is the final consequence of a variety of pathogenic events starting from alveolar stem cell exhaustion, and ending in a abnormal/dysplastic proliferation of bronchiolar epithelium. CT scan features of traction bronchiectasis and honeycombing should be interpreted under the light of these new pathogenetic and morphologic considerations.Short conclusion: We suggest that in IPF subjects traction bronchiectasis and honeycombing -now defined as distinct entities on HRCT scan-are actually diverse aspects of a continuous spectrum of lung remodeling.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.