Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort

Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. This study aimed to evaluate whether age acts as an independent determinant of asthma severity, clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to contol in different age groups. Lung function represented the most important age-related variable. On the opposite the level of asthma control was not differently distributed among age ranges. We can conclude that despite it cannot be considered a treatable trait, ageshould be evaluated within a personalized approach to severe asthma patients, in order to provide a more tailored treatment strategy. l