BackgroundCaffeine is the first-choice drug for the treatment for apnea of prematurity (AOP) in preterm infants and it has been reported that it improves the diaphragm activity. The aim of this study was to evaluate by ultrasound possible changes in diaphragm contractility and motility induced by caffeine. MethodsWe studied 26 preterm infants with gestational age <= 34 weeks treated with caffeine for the prevention or treatment of AOP. Diaphragmatic ultrasound was performed 15 min (T-0) before and 60 min (T-60) after the loading (20 mg/kg) or maintenance (5 mg/kg) dose of caffeine. ResultsDiaphragmatic excursion (DE) and thickness at the end of inspiration (DT-in) and expiration (DT-ex), as well as peak velocity of the excursion at the end of inspiration (DT-in) and expiration (DT-ex) increased after administration of both loading and maintenance dose of caffeine. ConclusionsUltrasounds confirmed that caffeine improves the activity of diaphragm in preterm infants improving its thickness, amplitude of excursions, and contraction velocity. These results are consistent with the effectiveness of caffeine in treating AOP and decreasing the risk of failure of noninvasive respiratory support in preterm infants with respiratory distress syndrome (RDS).

Effects of caffeine on diaphragmatic activity in preterm infants / Dani, Carlo; Fusco, Monica; Manti, Sara; Marseglia, Lucia; Ciarcià, Martina; Leonardi, Valentina; Corsini, Iuri; Gitto, Eloisa. - In: PEDIATRIC PULMONOLOGY. - ISSN 1099-0496. - STAMPA. - 58:(2023), pp. 2104-2110. [10.1002/ppul.26439]

Effects of caffeine on diaphragmatic activity in preterm infants

Dani, Carlo;Fusco, Monica;Corsini, Iuri;
2023

Abstract

BackgroundCaffeine is the first-choice drug for the treatment for apnea of prematurity (AOP) in preterm infants and it has been reported that it improves the diaphragm activity. The aim of this study was to evaluate by ultrasound possible changes in diaphragm contractility and motility induced by caffeine. MethodsWe studied 26 preterm infants with gestational age <= 34 weeks treated with caffeine for the prevention or treatment of AOP. Diaphragmatic ultrasound was performed 15 min (T-0) before and 60 min (T-60) after the loading (20 mg/kg) or maintenance (5 mg/kg) dose of caffeine. ResultsDiaphragmatic excursion (DE) and thickness at the end of inspiration (DT-in) and expiration (DT-ex), as well as peak velocity of the excursion at the end of inspiration (DT-in) and expiration (DT-ex) increased after administration of both loading and maintenance dose of caffeine. ConclusionsUltrasounds confirmed that caffeine improves the activity of diaphragm in preterm infants improving its thickness, amplitude of excursions, and contraction velocity. These results are consistent with the effectiveness of caffeine in treating AOP and decreasing the risk of failure of noninvasive respiratory support in preterm infants with respiratory distress syndrome (RDS).
2023
58
2104
2110
Goal 3: Good health and well-being
Dani, Carlo; Fusco, Monica; Manti, Sara; Marseglia, Lucia; Ciarcià, Martina; Leonardi, Valentina; Corsini, Iuri; Gitto, Eloisa
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1401943
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 2
social impact