Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by gastrointestinal symptom onset within 1-4 hours from trigger food ingestion. In the literature, some authors have previously described the possibility that a patient with FPIES may develop an IgE-mediated allergy to the same trigger food, especially cow's milk (CM). Case Presentation: We reported five cases of CM-FPIES converting to IgE-mediated CM allergy presented at our tertiary pediatric Allergy Unit and performed a review of the literature, aiming to characterize the clinical features of patients who are at risk of developing such conversion. Conclusions: This phenomenon raises the question of whether IgE-mediated and non-IgE-mediated allergies represent a spectrum of the same disease and highlights the need for further investigation to understand the pathophysiological mechanisms of this process.

Shift from Cow's Milk Food Protein-Induced Enterocolitis Syndrome to IgE-Mediated Allergy: Case Series and Literature Review / Barni, Simona; Pessina, Benedetta; Tóth, Viktória; Sarti, Lucrezia; Liccioli, Giulia; Tomei, Leonardo; Giovannini, Mattia; Mori, Francesca. - In: PEDIATRIC ALLERGY, IMMUNOLOGY, AND PULMONOLOGY. - ISSN 2151-3228. - ELETTRONICO. - 37:(2024), pp. 0-0. [10.1089/ped.2024.0023]

Shift from Cow's Milk Food Protein-Induced Enterocolitis Syndrome to IgE-Mediated Allergy: Case Series and Literature Review

Barni, Simona;Pessina, Benedetta;Sarti, Lucrezia;Liccioli, Giulia;Tomei, Leonardo;Giovannini, Mattia;Mori, Francesca
2024

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by gastrointestinal symptom onset within 1-4 hours from trigger food ingestion. In the literature, some authors have previously described the possibility that a patient with FPIES may develop an IgE-mediated allergy to the same trigger food, especially cow's milk (CM). Case Presentation: We reported five cases of CM-FPIES converting to IgE-mediated CM allergy presented at our tertiary pediatric Allergy Unit and performed a review of the literature, aiming to characterize the clinical features of patients who are at risk of developing such conversion. Conclusions: This phenomenon raises the question of whether IgE-mediated and non-IgE-mediated allergies represent a spectrum of the same disease and highlights the need for further investigation to understand the pathophysiological mechanisms of this process.
2024
37
0
0
Barni, Simona; Pessina, Benedetta; Tóth, Viktória; Sarti, Lucrezia; Liccioli, Giulia; Tomei, Leonardo; Giovannini, Mattia; Mori, Francesca...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1402823
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