Age-stratified analysis reveals arterial thrombosis as a predictor for gender-related second cancers in myeloproliferative neoplasms: a case-control study

Over the past decade, observational and population-based studies have documented an excess of solid tumors and lymphomas in patients with myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF), but the causes of this excess remain elusive [1–3]. It is well known that unprovoked venous thromboembolism (VTE) may precede second cancer (SC), but the possibility that arterial thrombosis may signal impending malignancy has only recently been explored in the general population [4]