Autoimmune encephalopathy associated with immunoglobulin G (IgG) autoantibodies binding to IgLON5 is characterized by a sleep disorder that includes sleep-disordered breathing and parasomnia, accompanied by gait disturbance, bulbar symptoms, dysautonomia, and cognitive decline.1 The effect of immunotherapy in patients with anti-IgLON5 disease remains unclear. We herein report the polysomnographic findings and the clinical and immunologic characteristics of a patient with IgLON5-IgG before and after 1 year of immunotherapy.
Immunotherapy improves sleep and cognitive impairment in anti-IgLON5 encephalopathy / Brunetti, Valerio; Della Marca, Giacomo; Spagni, Gregorio; Iorio, Raffaele. - In: NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION. - ISSN 2332-7812. - ELETTRONICO. - 6:(2019), pp. e577.0-e577.0. [10.1212/NXI.0000000000000577]
Immunotherapy improves sleep and cognitive impairment in anti-IgLON5 encephalopathy
Spagni, GregorioData Curation
;
2019
Abstract
Autoimmune encephalopathy associated with immunoglobulin G (IgG) autoantibodies binding to IgLON5 is characterized by a sleep disorder that includes sleep-disordered breathing and parasomnia, accompanied by gait disturbance, bulbar symptoms, dysautonomia, and cognitive decline.1 The effect of immunotherapy in patients with anti-IgLON5 disease remains unclear. We herein report the polysomnographic findings and the clinical and immunologic characteristics of a patient with IgLON5-IgG before and after 1 year of immunotherapy.
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