Methoxyisoflavone and ipriflavone may be of interest in sport doping because they can be used by athletes in the recovering period after the administration of anabolic steroids to increase the natural production of luteinizing hormone (LH) and consequently the biosynthesis of natural androgens [1]. Beyond this, priflavone and methoxyisoflavone act as competitive inhibitors of aromatase (CYP19) in vitro in a similar manner to formestane, anastrozole and aminoglutethimide, currently included in the WADA Prohibited List [2-3]
Human metabolism of synthetic isoflavones by GC-q-TOF / IANNONE, MICHELE; Silvia Parenti; Daniel Jardines; Francesco Botrè; Xavier de la Torre. - STAMPA. - (2017), pp. 80-85. (Intervento presentato al convegno XXXIV Cologne Workshop on Dope Analysis tenutosi a Colonia, Germania).
Human metabolism of synthetic isoflavones by GC-q-TOF
Francesco Botrè;
2017
Abstract
Methoxyisoflavone and ipriflavone may be of interest in sport doping because they can be used by athletes in the recovering period after the administration of anabolic steroids to increase the natural production of luteinizing hormone (LH) and consequently the biosynthesis of natural androgens [1]. Beyond this, priflavone and methoxyisoflavone act as competitive inhibitors of aromatase (CYP19) in vitro in a similar manner to formestane, anastrozole and aminoglutethimide, currently included in the WADA Prohibited List [2-3]
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