Modeling of time domain diffuse Raman spectroscopy in a two-layer medium

A model, based on the solution of two coupled diffusion equations to the excitation and emission wavelengths, respectively, was developed to describe the Raman signal in the time domain in a reflectance configuration in a two-layer medium. The accuracy of the model is characterized by comparison with the results of Monte Carlo simulations. This solver can correctly account for the Raman emitters within the layers and the full wavelength dependence of the optical properties of the layers. The short computation time of this solver makes it suitable for use in reconstructing Raman spectra from time domain measurements at multiple wavelengths.