The Higher Order Structure (HOS) of multispecific biologics and conventional monoclonal antibodies can be analyzed by examining the molecular 'fingerprint' they leave on the target through solid-state NMR (SSNMR).
NMR reveals the binding mode of three different full-length clinically approved monoclonal antibodies for the same target / Linda Cerofolini, Rebecca Calamandrei, Francesca Sacco, Bianca Susini, Sara Callozzo, Pasquale Russomanno, Enrico Ravera, Fabio Baroni, Marco Fragai. - ELETTRONICO. - (2025), pp. 66-66. ( XIV International Congress "NMR: a tool for biology" 2025).
NMR reveals the binding mode of three different full-length clinically approved monoclonal antibodies for the same target
Linda Cerofolini;Rebecca Calamandrei;Francesca Sacco;Bianca Susini;Sara Callozzo;Pasquale Russomanno;Enrico Ravera;Marco Fragai
2025
Abstract
The Higher Order Structure (HOS) of multispecific biologics and conventional monoclonal antibodies can be analyzed by examining the molecular 'fingerprint' they leave on the target through solid-state NMR (SSNMR).
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