This study investigates the role of the GLRX3-BOLA2 complex in the maturation of [4Fe-4S] clusters within the human cytosolic iron-sulfur assembly pathway. Using spectroscopic and biochemical approaches, including UV-vis absorption, paramagnetic NMR, and anaerobic reconstitution assays, we reveal mechanistic insights into cluster transfer and stabilization. These findings shed light on the molecular processes underlying iron-sulfur protein biogenesis in human cells.
BOLA2 and GLRX3: keyplayers in human cytosolic [4Fe-4S] cluster assembly / Martina Masini, Francesca Camponeschi, Lucia Banci. - ELETTRONICO. - (2025), pp. 1-1. ( Action Scientific Meeting 2025 FeS Clusters Ancient Cofactors, Emerging Functions).
BOLA2 and GLRX3: keyplayers in human cytosolic [4Fe-4S] cluster assembly
Martina Masini;Francesca Camponeschi;Lucia Banci
2025
Abstract
This study investigates the role of the GLRX3-BOLA2 complex in the maturation of [4Fe-4S] clusters within the human cytosolic iron-sulfur assembly pathway. Using spectroscopic and biochemical approaches, including UV-vis absorption, paramagnetic NMR, and anaerobic reconstitution assays, we reveal mechanistic insights into cluster transfer and stabilization. These findings shed light on the molecular processes underlying iron-sulfur protein biogenesis in human cells.
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