This work explores the role of human GLRX3 in cytosolic [Fe-S] cluster assembly, focusing on its function in transferring [2Fe-2S] clusters to NUBP1 for [4Fe-4S] maturation. Using domain-specific constructs and mutants expressed in E. coli, we investigated GLRX3’s contribution through biochemical and spectroscopic approaches (UV-Vis, NMR, SEC).
Unraveling The Function Of GLRX3 Domains In The Maturation Of Human Cytosolic Fe-S Proteins / Rosanna Cuccaro, Francesca Camponeschi, Lucia Banci. - ELETTRONICO. - (2025), pp. 1-1. ( Action Scientific Meeting 2025 "FeS Clusters Ancient Cofactors, Emerging Functions").
Unraveling The Function Of GLRX3 Domains In The Maturation Of Human Cytosolic Fe-S Proteins
Rosanna Cuccaro;Francesca Camponeschi;Lucia Banci
2025
Abstract
This work explores the role of human GLRX3 in cytosolic [Fe-S] cluster assembly, focusing on its function in transferring [2Fe-2S] clusters to NUBP1 for [4Fe-4S] maturation. Using domain-specific constructs and mutants expressed in E. coli, we investigated GLRX3’s contribution through biochemical and spectroscopic approaches (UV-Vis, NMR, SEC).
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