This study explores the use of Fast Field-Cycling (FFC) NMR Relaxometry to investigate the molecular dynamics and relaxivity of paramagnetic gadolinium (Gd)-based complexes used as MRI contrast agents. A new graphical fitting software is being developed to facilitate the analysis of relaxation profiles from proteins. As a case study, human transthyretin (TTR) was tagged with the Gd-C4-IA complex to evaluate its potential as a theranostic agent. The results demonstrate a significant enhancement in relaxivity for the GdTTR conjugates, highlighting their promise for combined diagnostic and therapeutic applications.
RELAXOMETRIC STUDIES TO REVEAL POTENTIAL THERANOSTIC PROPERTIES OF HUMAN TRANSTHYRETIN CONJUGATED WITH GD(III) COMPLEXES / A. Kubrak, J. Bindi, M. Fragai, P. Sebastiao, G. Parigi. - ELETTRONICO. - (2024), pp. 25-25. (Intervento presentato al convegno 13th FFC NMR Conference).
RELAXOMETRIC STUDIES TO REVEAL POTENTIAL THERANOSTIC PROPERTIES OF HUMAN TRANSTHYRETIN CONJUGATED WITH GD(III) COMPLEXES
A. Kubrak;J. Bindi;M. Fragai;G. Parigi
2024
Abstract
This study explores the use of Fast Field-Cycling (FFC) NMR Relaxometry to investigate the molecular dynamics and relaxivity of paramagnetic gadolinium (Gd)-based complexes used as MRI contrast agents. A new graphical fitting software is being developed to facilitate the analysis of relaxation profiles from proteins. As a case study, human transthyretin (TTR) was tagged with the Gd-C4-IA complex to evaluate its potential as a theranostic agent. The results demonstrate a significant enhancement in relaxivity for the GdTTR conjugates, highlighting their promise for combined diagnostic and therapeutic applications.
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FFCNMRConference_Palermo2024_BoA.pdf
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